Although pro‐inflammatory cytokine, particularly TNF‐α has been implicated in the development of salt‐sensitivity and hypertension (Majid et al., 2015; Rodríguez‐Iturbe et al., 2014; Schiffrin, 2013), earlier investigations in our laboratory (Shahid et al., 2008) demonstrate that TNF‐α administration induces the diuretic and natriuretic responses which indicate that TNF‐α plays a counter‐regulatory role in the mediation of salt‐sensitive hypertension. Here, TNF is linked to hypertensive disorder.