Both Tim4‐αCD41 (ρ = 0.511, P = 0.0214) and Tim4‐αCD61 (ρ = 0.684, P < 0.001) were positively correlated with MMSE score, suggesting that CD41‐ and CD61‐positive EVs are elevated in the early stages of AD relative to late‐stage AD. Here, ITGA2B is linked to Alzheimer disease.