DIAPH3 and familial pancreatic carcinoma: In order to further confirm this function, we also used pancreatic cancer cell lines Mia Paca‐2 and CFPAC‐1 with DIAPH3 knock down to conduct a study and found that the invasive capacity of pancreatic cancer cells was greatly weakened after knock down of DIAPH3 (Figure 3B and D), likewise, DIAPH3 did not have an impact on cell proliferation of Mia Paca‐2 and CFPAC‐1 under this low serum culture concentration (0.1%) within 48 hours (Figure S2B and C).