After overexpressing DIAPH3 in pancreatic cancer cells, its invasive capacity was greatly enhanced, which was verified in SW1990 cell lines (Figure 3A and C), while DIAPH3 did not affect cell proliferation under this low serum culture concentration (0.1%) within 48 hours (Figure S2A), which rules out the possibility of false‐positive observation of DIAPH3 enhanced invasion resulted from DIAPH3‐induced proliferation. The gene discussed is DIAPH3; the disease is familial pancreatic carcinoma.