Therefore, we speculated that DIAPH3 may interact with key genes of various selenoamino acid metabolic pathways in pancreatic cancer to significantly impact the functions of genes related to selenoamino acid metabolic pathways, and promote selenoprotein (such as TrxR1 or GPX4) synthesis, which direct reduction of hydroperoxides or resist ferroptosis, respectively. This evidence concerns the gene GPX4 and familial pancreatic carcinoma.