Specifically, we will show that KCNQ1OT1 and miR-124 mediate RB cell progression possibly via regulating SP1 expression and silent information regulator 1 (SIRT1)/c-Jun N-terminal kinase (JNK) signaling, which are strongly associated with tumor cell proliferation, apoptosis, and migration [15–17]. The gene discussed is SIRT1; the disease is neoplasm.