GSEA pathway enrichment analysis further showed low expression of CXCL10 in multiple cancer pathways (p53 signaling pathway, Cell cycle, Pathways in cancer, Colorectal cancer signal pathway).The LinkedOmics database was used to explore the top 50 positively and negatively correlated genes and kinase targets of CXCL10.As shown in Figure 5B,C, the top five genes negatively associated with CXCL10 were CXCL11, CXCL9, GBP5, UBD, and IL12RB1 and the top five genes positively associated with CXCL10 were CMTM4, TOM1L2, LCLAT1, CRY2, and PCBD2 with CXCL10. This evidence concerns the gene IL12RB1 and cancer.