In our experiments, Significant correlations were detected between CXCL10 and expression of immune markers, including PD-1 (PDCD1), CD2, CD19, CD79A, CD68, IL10, VSIG4, HLA-DPB1, CD11c (ITGAX), T-bet (TBX21), STAT1, IFN-g (IFNG), FOXP3 and CTLA4, suggesting that the CXCL10 gene exerts its effects in the thyroid cancer microenvironment by influencing immune cells and related molecules. This evidence concerns the gene TBX21 and thyroid cancer.