In our experiments, Significant correlations were detected between CXCL10 and expression of immune markers, including PD-1 (PDCD1), CD2, CD19, CD79A, CD68, IL10, VSIG4, HLA-DPB1, CD11c (ITGAX), T-bet (TBX21), STAT1, IFN-g (IFNG), FOXP3 and CTLA4, suggesting that the CXCL10 gene exerts its effects in the thyroid cancer microenvironment by influencing immune cells and related molecules. The gene discussed is IFNG; the disease is thyroid cancer.