It has been shown that HK mRNA in adipose tissue is upregulated after 180 min of insulin stimulation in metabolically healthy and obese men and women, but not in type 2 diabetes patients, suggesting that acute insulin dependent upregulation of HK is impaired due to or maybe as a path in adipose tissue insulin resistance (Ducluzeau et al., 2001). The gene discussed is INS; the disease is type 2 diabetes mellitus.