Elevated concentration of CORT, the main stress hormone in rodent models, has been associated with depressive- and anxiety-like behaviours (Rosa et al., 2014; Mendez-David et al., 2017); and accumulating lines of evidence indicate that depressive or chronically stressed individuals have an over activated HPA axis, which ultimately is involved in the release of CORT to the bloodstream (Pariante and Lightman, 2008; Keller et al., 2017). Here, CORT is linked to Anxiety.