Because all cardiovascular alterations in Dhigh recovered earlier (after day 5 for LF/HF, SBP and DBP; after day 11 for HF and after day 15 for BRS and VPBs) than circulating BDNF levels (after day 20, Brouillard et al., 2019), we can't exclude that cardiac disorder in our study may result in hippocampal BDNF depletion. This evidence concerns the gene BDNF and hydrops fetalis.