Through the analysis of GO enrichment and KEGG pathway of key targets, it was found that RC can alleviate hyperglycemia, oxidative stress, abnormal glycolipid metabolism, inflammation, and renal fibrosis and inhibit transcription factors and cell migration to protect renal function and to delay DN progression through the regulation of AGE-RAGE and IL-17 signaling pathways. The gene discussed is IL17A; the disease is renal fibrosis.