BRAF and melanoma: For example, PLB caused the reduction of cell proliferation, induction of apoptosis, and disruption of mitochondrial membrane potential in BRAF-mutated (SK-MEL-28, WM35, and RPMI-7951), NRAS-mutated (SK-MEL-119), and BRAF/NRAS wild-type (Hs294T) melanoma cells by ROS-mediated disruption of mitochondrial membrane potential and inhibition of PI3K/AKT/mTOR signaling [38].