AKT1 and neoplasm: Wei et al. [22] demonstrated the finding that PLB restrained hepatocellular carcinoma angiogenesis (SMMC-7721 and Hep3B) by suppressing the migration and invasion of tumor-derived vascular endothelial cells, which was associated with suppressing the expression of angiogenesis pathways (PI3K-Akt, VEGF/KDR, and angiopoietins/Tie2) and angiogenic factors (VEGF, CTGF, ET-1, and bFGF).