AKT1 and neoplasm: Hafeez et al. [42] confirmed PLB inhibited C57BL/6 wild-type mice tumor growth in intact as well as in a castrated Pten-KO mouse model possibly via inhibition of PKCe, Stat3, AKT activation, and epithelial-to-mesenchymal transition (EMT) markers (Vimentin and Slug).