Elevated levels of pro-inflammatory cytokines (IL-6, TNF-α), adipokines (Leptin, adiponectin, ghrelin), LAR, prothrombotic factors (PAI-1), uric acid, and pro-oxidant (oxidized LDL) coupled with lower levels of anti-inflammatory cytokines (IL-10) and antioxidant factors (PON-1) are noted in metabolic syndrome (7). The gene discussed is TNF; the disease is metabolic syndrome.