In relation to hyperlipidemia-induced ROS production and mitochondrial dysfunction associated with development of insulin resistance in skeletal muscle, we evaluated expression of genes encoding proteins with pro- and antioxidant properties and found out that HFI-419 treatment elevates the Sod1 and Sod2 mRNA levels while the expression of prooxidative genes (Nox4 and Cyba) did not change. The gene discussed is NOX4; the disease is hyperlipidemia.