We and other authors have previously shown that obesity is associated with dysregulation of IRAP activity in adipose tissue and skeletal muscle along with reduced plasma oxytocin due to increased peptide degradation by peripheral tissues (Gajdosechova et al., 2014; Alponti et al., 2015). The gene discussed is LNPEP; the disease is obesity due to melanocortin 4 receptor deficiency.