Results have revealed that insulin regulated traffic of IRAP toward membrane fraction in adipocytes is disturbed by monosodium glutamate-induced obesity (Alponti et al., 2015) and IRAP deficiency in mice fed high-fat diet lead to prevention of development of obesity (Niwa et al., 2015). The gene discussed is LNPEP; the disease is obesity due to melanocortin 4 receptor deficiency.