It is required, subsequently, a panel of immune markers for sub-classification, like: TdT, CD34, Cd117, and CD99 for ALL/LBL (9); CD5, SOX11, and CCND1 for MCL (20); CD3, CD56, TIA-1, GZM-B, and EBER-ISH for ENKTCL (11). This evidence concerns the gene TIA1 and acute lymphoblastic leukemia.