IL10 and Sepsis: Furthermore, Venet et al. and Carson et al. showed that sepsis induced an increase in the proportion of anti-inflammatory immune cells (such as Tregs) that release anti-inflammatory cytokines (such as IL10), which resulted in epigenetic alterations of naïve immune cells and further suppressed inflammatory activation-related pathways (such as the Toll-like receptor signaling pathway) (21, 22).