Thus, the damage and inefficiency of the immune system caused by lymphopenia, T cell exhaustion and cytokine release syndrome, and organ specific ACE2 expressing cells (endothelial, alveolus in lungs, proximal tubule, and glomerulus in kidneys, pericytes in heart, ect) could potentially lead to complications like acute respiratory disease syndrome and multi-organ failure. The gene discussed is ACE2; the disease is lymphopenia.