Immunohistochemical evaluation of ACE2 presence in healthy and oncologic patients showed ACE2 in basal cell layer of normal epidermis and sebaceous glands and a reduction of ACE2 reactivity in patients affected by pre-malignant lesions (actinic keratosis) and non- melanoma malignant skin cancers (basal cell carcinoma and squamous cell carcinoma), suggesting an involvement in the pathogenesis of the disease (58). The gene discussed is ACE2; the disease is actinic keratosis.