MTOR and gastric cancer: Sun et al. (2017) have shown that CISD2 is significantly down-regulated in gastric cancer tissues and drug-resistant cell lines, which contributes to the resistance of gastric cancer cells to 5-FU. Further studies have found that CISD2 overexpression antagonizes 5-FU-induced autophagy by increasing the phosphorylation levels of AKT (S473) and mTOR (Ser2448), consequently reversing the reduction of p-MTOR and p-AKT by 5-FU and enhancing the sensitivity of MKN1 and BGC823 cells to 5-FU (Sun et al., 2017).