MGMT and gastric cancer: Lei et al. (2020) have found that the high expression of MGMT is significantly correlated with the low expression of ATG4B and the favorable prognosis of gastric cancer. DDP can inhibit MGMT expression in a dose- and time-dependent manner and the low expression of MGMT can, in turn, induce autophagy and cisplatin resistance. Overexpression of MGMT can inhibit autophagy and reverse DDP resistance in vivo and in vitro (Lei et al., 2020).