Moreover, miR-16-1-3p mimics increased expression of E-cadherin, an epithelial marker, and decreased that of Vimentin, a mesenchymal marker (Figure 4G), while anti-16-1-3p had opposite effects (Figure 4H), suggesting that miR-16-1-3p may regulate epithelial-mesenchymal transition (EMT), a process critical for cancer cell migration and invasion. This evidence concerns the gene VIM and cancer.