Recently, DDX11 was considered to have carcinogenic potential in clear cell renal cell carcinoma (ccRCC), lung adenocarcinoma (ADC), and melanoma (Bhattacharya et al., 2012; Li et al., 2019; Park et al., 2020a,b), despite that its specific roles and mechanisms in cancers are unclear (Petrakis et al., 2016). The gene discussed is DDX11; the disease is lung adenocarcinoma.