Lovén et al. (2013) identified 681 SE-associated genes, including some key MM genes such as MYC, IRF4, PRDM1, and XBP1. Jin et al. (2018) found 55 recurrent transcription factor (TF) associated SEs in MM samples and established a SE-TF regulatory network, which provided some critical TFs to target in MM. Besides, MM cell growth was driven by non-overlapping controlled transcription of promoters and SEs (Fulciniti et al., 2018). Here, PRDM1 is linked to Miyoshi myopathy.