Since CSGALNACT1, FAM53B, TAPBPL, REPIN1, and DDX11 are SE-associated genes, and their roles have not been elucidated in MM, we recommend conducting functional studies of these five genes in the near future, and the in-depth evaluation of the five-gene risk model in prospective cohorts are also needed. This evidence concerns the gene FAM53B and Miyoshi myopathy.