A nine-gene prognostic signature (HLA-DPB1, TOP2A, FABP5, CYP1B1, IGHM, FANCI, LYZ, HMGN5, and BEND6) related to the ISS stage of MM was developed via weighted gene co-expression network analysis (WGCNA) and Lasso (Liu et al., 2018). This evidence concerns the gene HMGN5 and Miyoshi myopathy.