Clinical information of pSS including demographic (age and disease duration), symptomatic (xerostomia and xerophthalmia), serological [immunoglobulin G (IgG), complement 3 (C3), ESR, anti-nuclear antibody (ANA), anti-SSA/Ro, and anti-SSB/La], and histological features (focus score ≥ 1) are clustered in Figure 3A. This evidence concerns the gene C3 and Keratoconjunctivitis sicca.