In the oral squamous cell carcinoma (OSCC) (Zhao et al., 2020b) and hepatocellular carcinoma (HCC) (Wei et al., 2020), miR-526b could function as a tumor suppressor, inhibited cell growth by targeting c-Myc, and miR-526b also acts as a tumor suppressor in gastric cancer by targeting YAP1. This evidence concerns the gene MYC and oral cavity squamous cell carcinoma.