MITF and Waardenburg syndrome: Moreover, the interaction between SOX10 and paired box gene 3 (PAX3) is considered a regulator of genes related to symptoms of Waardenburg syndrome, particularly microphthalmia-associated transcription factor (MITF), which is a basic helix-loop-helix leucine zipper transcription factor that is involved in a lineage-specific pathway that regulates various cells, including melanocytes (Dynek et al., 2008), osteoclasts (Hershey and Fisher, 2004), and mast cells (Martina et al., 2014).