TCF7L2 and familial pancreatic carcinoma: For instance, transcription factor 7-like 2 (TCF7L2) is one transcriptional partner of the Wnt/β-catenin pathway regulating aerobic glycolysis in pancreatic cancer (Xiang et al., 2018), which showed significantly lower dimethylation in PANC-1 cells in our quantitative proteomics.