Patient P14, a 3-year-old girl referred to our hospital with severe cerebral meningitis, convulsion, pneumonia, respiratory failure, and abnormal hepatic function, whereas Patient 15, a 6-month-boy had hepatosplenomegaly, hypertrophic cardiomyopathy, and abnormal laboratory examination including increased transaminase (ALT 142U/L, AST 217U/L) and CK level (681U/L). This evidence concerns the gene GPT and hypertrophic cardiomyopathy.