NLRX1 and neuroblastoma: In NLRX1 knock-in (KI) neuroblastoma cells, NLRX1 associated with GTPase dynamin-related protein 1 (DRP1), a major regulator of mitochondrial dynamics, resulted in increased mitochondrial fission, and the mitochondria in these cells showed morphological abnormalities (Imbeault et al., 2014).