Interestingly, different lipids such as coenzyme A-containing fatty acids and sterols were shown to bind the LRR domain of NLRX1 and punicic acid (PUA), a polyunsaturated fatty acid, exerted anti-inflammatory effects in a NLRX1-dependent manner in LPS-activated BMDMs or in a DSS-induced colitis mice model (Lu et al., 2015). Here, NLRX1 is linked to colitis.