PCYT1B and infection: A good example of this phenomenon is the experimental model of leishmaniasis where susceptible BALB/c mice treated with Cts B inhibitor (CA074) acquired resistance to infection with Lieshmania major characterized by the shift from Th2 to Th1 immune response, suggesting that Cts B preferentially activates a Th2 response (Maekawa et al., 1998).