IFNA1 and parasitic infectious disease: Constant human recombinant IFN-α treatment also resulted in enhanced survival, which was associated with an IFN-γ–mediated decrease of parasitemia, expression of intracellular adhesion molecule-1 (ICAM-1 or CD54) in the brain, and CD8+ T cells sequestration (Vigario et al., 2007) (Figure 3B).