Additionally, the levels of IFN-γ and IL-6 were also higher in mice with elevated early IFN-Is than infections with low IFN-Is, suggesting that IFN-γ, IL-6 and other cytokines may contribute to the reduction of parasitemia and better host survival (Yu et al., 2016; Wu et al., 2020). This evidence concerns the gene IFNG and parasitic infectious disease.