SP1 regulates the metastasis in LSCC, promotes cell migration and invasion in OSCC by upregulating Annexin A2 transcription, and downregulation of SP1 inhibits the growth of oral cancer cell SCC-15, YD-15 (Cai et al., 2012; Shin et al., 2013; Liu et al., 2019). The gene discussed is SP1; the disease is lip and oral cavity carcinoma.