Constitutively active NF-κB has been documented in HNSCC cell lines (Ondrey et al., 1999), and primary (Mishra et al., 2006; Bano et al., 2018; Gupta et al., 2018) and recurrent metastatic HNSCC (Li Z. et al., 2015). Here, NFKB1 is linked to head and neck squamous cell carcinoma.