Because of the overlapping role of NF-κB and AP-1 in inflammation and cancer, many studies investigated the role of these transcription factors together (Ondrey et al., 1999; Wolf et al., 2001; Chen et al., 2008) and their pharmacological targeting effectively attenuated expression of oncogenes HPV16 E6/E7 in HNSCC (Bancroft et al., 2002; Mishra et al., 2015). Here, FOSB is linked to head and neck squamous cell carcinoma.