STAT3 modulates the expression of multitude of genes that are involved in cell proliferation, differentiation, apoptosis, cell cycle regulation, angiogenesis, EMT and immune invasion during development of HNSCC [reviewed by (Lai and Johnson, 2010; Masuda et al., 2010; Johnson et al., 2018)]. This evidence concerns the gene STAT3 and head and neck squamous cell carcinoma.