TP53 and head and neck squamous cell carcinoma: Reduced p53 transcript in HPV-positive tumors was associated with activation of oncogenic pathway genes such as CDKN2A/CCND1 and other candidate transcript genes such as SFRP1, CRCT1, DLG2, SYCP2, and CRNN with SYCP2, which contribute to genetic instability during development of HNSCC (Masterson et al., 2015).