Aberrant activation and dysregulation of NF-κB signalling is reported in many cancer types including colon, breast, pancreatic, leukemia, myeloma, cervical, and HNSCC (Bours et al., 1994; Dokter et al., 1995; Sovak et al., 1997; Wang et al., 1999; Bharti et al., 2003; Prusty et al., 2005; Gupta et al., 2018). Here, NFKB1 is linked to head and neck squamous cell carcinoma.