Intriguingly, F-box and leucine rich repeat protein 19 (FBXL19), the complementary gene of FBXL19-AS1, was also up-regulated in HCC and was found to be negatively correlated with the amount of macrophage M1 in the high FBXL19 group of HCC tissues. This evidence concerns the gene FBXL19 and hepatocellular carcinoma.