Thereafter, hub genes identified by 12 algorithms (MCC, DMNC, MNC, Degree, EPC, BottleNeck, EcCentricity, Closeness, Radiality, Betweenness, Stress, ClusteringCoefficient) constituted a subnetwork with 9 nodes and 9 edges (Figure 8C), which revealed the 9 hub genes (STAT3, CNOT7 BTG3, E2F1, TRIM37, YWHAZ, RBBP7, KIF23, ESR1) played important roles in the pathogenesis of HCC. This evidence concerns the gene ESR1 and hepatocellular carcinoma.