4-((((2-((1-(3-((2-oxo-2h-chromen-7-yl)foxy)propyl)1h-1,2,3-triazol-4-yl)methoxy)naphthalen-1-yl)-methylene)amino) methyl) benzenesulfonamide (8i) exhibited the ability of selective inhibition of cell proliferation via specific inhibition of CA IX and CA XII expression in human colon cancer cells with the Ki is 45.5nM and 596.6 nM, respectively. Here, CA12 is linked to malignant colon neoplasm.