Esculetin, a kind of 6,7-dihydroxyl derivative, can be found in various medicinal plants, such as Cichorium intybus, Artemisia capillaries, Ceratostigma willmottianum, Citrus limonia, etc. Arora (28) treated three kinds of pancreatic cancer cell lines with esculetin, and found that the expression of caspase-3, -8, and -9, as well as the activation level and cleavage form in pancreatic cancer cell lines, were significantly increased. This evidence concerns the gene CASP3 and pancreatic neoplasm.