These coumadin hybrids can up-regulate the expression of caspase-3 proteins in HCC cell lines and caspase-3 and caspase-9 proteins in leukemia cell lines, and down-regulate the expression of Bcl-2 and the up-regulation of Bax protein expression levels in HCC and leukemia cell lines. The gene discussed is CASP3; the disease is hepatocellular carcinoma.