These coumadin hybrids can up-regulate the expression of caspase-3 proteins in HCC cell lines and caspase-3 and caspase-9 proteins in leukemia cell lines, and down-regulate the expression of Bcl-2 and the up-regulation of Bax protein expression levels in HCC and leukemia cell lines. Here, BCL2 is linked to hepatocellular carcinoma.