VEGFA and neoplasm: The results showed that the LD50 value of UMB-07 was about 1000 mg/kg, and at the concentration of 50 mg/kg, UMB-07 had significant anti-tumor activity in vivo, indicating that UMB-07 was a good candidate anti-tumor drug worthy of further study. The main antitumor mechanism of UMB-07 is the inhibition of tumor angiogenesis by reducing chemokine CCL2, and CCL2 is important to tumor neovascularization by inducing increased VEGF in tumor microenvironment.