UBA1 and hepatocellular carcinoma: UBA1 exhibited high expression in HCC samples in the GSE22058 (n=192), GSE54238 (n=23), and TCGA HCC RNA-Seq dataset s (n=421) (Figures 6A–C), and the increasing expression of UBA1 was significantly associated with poor survival in the Cancer Genome Atlas Liver Hepatocellular Carcinoma (TCGA-LIHC) cohort (Figure 6D; n=369; HR=1.49; p=0.026).