Correlation analysis was performed for HCC samples obtained from the TCGA HCC RNA-Seq cohort to examine the association between UBA1 and the key OS gene Nrf2. The UBA1 level was positively correlated with Nrf2 (Figure 9A; r=0.179, p=5.13e-04) and might serve as the key gene involved in the OS response pathway. The gene discussed is NFE2L2; the disease is hepatocellular carcinoma.