Cluster EZB (22% of DLBCL) resembles C3 and the genomic lesions of GCB DLBCL with lesions in genes coding for proteins involved in chromatin regulation (EZH2 mutations, KMT2D mutations, CREEBBP or EP300 mutations or deletions), apoptosis (BCL2 translocations), immune escape (TNFRSF14 mutations or deletions), cell motility (GNA13 mutations), JAK/STAT signaling (STAT6 mutations or amplifications, SOCS1 mutations or deletions), PI3K/AKT signaling (PTEN deletions, mTOR mutations, and MIR17HG amplifications), immune escape (inactivation of TNFRSF14, CIITA, HLA-DMA), and REL amplifications. The gene discussed is EZH2; the disease is diffuse large B-cell lymphoma.