Deregulation of MYC via DNA gains, amplifications or chromosomal translocation is the most frequent event occurring at the transformation from FL to DLBCL, followed by inactivation, mainly by DNA loss, of CDKN2A/B, of B2M (losses or mutations) and activating mutations of P1M1 (28, 61). The gene discussed is CDKN2A; the disease is diffuse large B-cell lymphoma.