These connections are evident for C5, MCD, MYD88 (primary extranodal DLBCL of the central nervous system or of the testis; transformed Waldenström macroglobulinemia), C3, EZB, BCL2 [follicular lymphoma (FL); transformed FL; Burkitt lymphoma), N1 [(NOTCH1 mutated chronic lymphocytic leukemia (CLL)], C2, BN2, NOTCH2 (transformed MZL), and ST2 (nodular lymphocyte-predominant Hodgkin lymphoma; T cell/histiocyte-rich large B cell lymphoma) (19–21, 54). The gene discussed is NOTCH1; the disease is diffuse large B-cell lymphoma.