Genetically, GCB and ABC DLBCL present a series of subtype-specific lesions that explain can explain the different biology of the disease, but they also share others that, with a couple of exceptions (BCL6 and MEF2B alterations), are not DLBCL specific and can be observed in other lymphoma types or even in other cancers. The gene discussed is BCL6; the disease is diffuse large B-cell lymphoma.