The BN2 (15% of DLBCL), similar to C1, contains both GCB and ABC DLBCL and it is enriched of cases with Notch activation (NOTCH2 mutations or amplifications, mutations of DTX1 or SPEN), BCL6 translocations, NF-κB signaling (inactivation of TNFAIP3 or TN1P1 and gains or amplification of PRKCB and BCL10), immune escape (CD70 inactivation), cell cycle (CCND3 mutations), and cell migration (CXCR5). The gene discussed is SPEN; the disease is diffuse large B-cell lymphoma.