Moreover, following the development of a double-hit gene expression signature identifying GCB-DLBCL patients with no evidence of a dual hit at FISH analysis but an outcome similar to the double-hit patients (36), the EZB group has been divided based on the presence (EZB-MYC+) or absence (EZB-MYC-) of a double hit (DHIT) signature (21). Here, MYC is linked to diffuse large B-cell lymphoma.