DTX1 and diffuse large B-cell lymphoma: The BN2 (15% of DLBCL), similar to C1, contains both GCB and ABC DLBCL and it is enriched of cases with Notch activation (NOTCH2 mutations or amplifications, mutations of DTX1 or SPEN), BCL6 translocations, NF-κB signaling (inactivation of TNFAIP3 or TN1P1 and gains or amplification of PRKCB and BCL10), immune escape (CD70 inactivation), cell cycle (CCND3 mutations), and cell migration (CXCR5).