Hypoxia in the local microenvironment can promote the formation of new blood vessels by inducing Hypoxia-inducible factor 1-alpha (HIF-1α) (6), Vascular endothelial growth factor (VEGF) (7), C-C Motif Chemokine Ligand 28 (CCL28) (8) and other cytokines, and regulate the expression of the signal cascade and downstream related genes, thereby promoting the proliferation and invasion of tumor cells (9). Here, HIF1A is linked to neoplasm.