The pathway enrichment analysis showed that the DEGs in the sub-network linked to hypoxia and tumor related pathways: HIF-1 signaling pathway, Transcriptional misregulation in cancer, Bladder cancer, Central carbon metabolism in cancer, Glycolysis/Gluconeogenesis, AMPK signaling pathway, etc. (Figure 3C, Table S2). The gene discussed is SETD2; the disease is cancer.