The key markers of hypoxia (ALDOA, ENO1, LDHA, etc.)are highly expressed in the hypoxiahigh/immunelow group, while a higher percentage of CD8+ T cells was observed in the hypoxialow/immunehigh group (40). In this case, both their and our results confirmed that there is a strong positive correlation between the hypoxia status of tumor and immunosuppression. This evidence concerns the gene LDHA and neoplasm.