The analysis of clinicopathological and prognostic features revealed that patients with low expression of miR-631 were significantly associated with cirrhosis, multiple tumors, incomplete tumor encapsulation, poor tumor differentiation, high TNM stage, short disease-free survival time and short overall survival time, and had no significant difference in gender, age, alpha-fetoprotein (AFP) expression, Child–Pugh class, tumor size, and lung metastasis. This evidence concerns the gene AFP and neoplasm.