It revealed same outcome like above that, PIK3CA knockdown weaken the proliferation, migration, invasion and angiogenesis capabilities of EJ and T24T cells, however restoration of CUX1 overexpression rescued bladder cancer cells from their defects resulted from knockdown of CUX1 (Supplementary Figures S5A–E). This evidence concerns the gene CUX1 and urinary bladder carcinoma.