The iRGD peptide‐containing nanoparticles may penetrate tumor blood vessels and tissue through interactions with αvβ3 integrin and neuropilin‐1 (NRP‐1) and cross the BBB to reach the glioma cells.[14] These multifunctional iRPPA@TMZ/MnO nanoparticles have been designed to be triggered by the TME of glioma tosimultaneously produce TMZ, Mn2+, and O2. This evidence concerns the gene NRP1 and central nervous system cancer.