In clinic practice, needle biopsies are commonly utilized prior to targeted therapy to examine the adequacy of target expression in tumor tissues however, but this approach is limited by its invasiveness and lack of accuracy (<50%) due to the intratumoral complexity and heterogeneity.[32] To overcome these obstacles, we have developed a novel ICAM1‐targeting MRI probe and have used it to map the tumoral ICAM1 expression in an orthotopic PC model using MRI (Figure 4A). This evidence concerns the gene ICAM1 and pachyonychia congenita.