The McDevitt laboratory proposed different approaches for a programmable Bio Nano Chip (pBNC) for the detection of disease biomarkers, such as the ovarian cancer associated cancer antigen 125 (CA125)[177, 178] and HE4, MMP‐7 and CA72‐4.[178] The “programmable” refers to the ability of the chip to be redesigned for different biomarkers. The gene discussed is MMP7; the disease is ovarian carcinoma.