The immunosensing strategy for kinase sensing was also applied by other groups to study the activity of human epidermal growth factor receptor 2 (Her2)[140] and nonreceptor tyrosine kinase Abl and Scr (which play part in the progression of cancer).[141] The sensing of Her2 activity was part of a multiplex detection assay for identifying the activity of urokinase type plasminogen activator (known to degrade the extracellular matrix and promote breast cancer invasion and metastasis) and Her2 (Her2 overexpression is associated with higher resistance to certain cancer treatments) simultaneously. The gene discussed is ERBB2; the disease is breast carcinoma.