MKI67 and neoplasm: Highly significant necrosis of tumor cells in the ZrC, ZrC@Iri and ZrC@prodrug groups were checked compared to the control, and ZrC@prodrug and ZrC@Iri induced a higher cell apoptosis rate (TUNEL) with lower cell proliferative activities (Ki67) in tumor compared to the control (Figure 4d), indicating ZrC@prodrug had a similar anti‐tumor effect compared with ZrC@Iri.