The KEGG analysis showed that the pathway of genes in the network were mostly related with Hepatitis B (hsa05161, 4 genes were enriched with P = 0.003), GnRH signaling pathway (hsa04912, 3 genes were enriched with P = 0.005), and Prion disease (hsa05020, 2 genes were enriched with P = 0.007) (Fig. 4D). This evidence concerns the gene GNRH1 and prion disease.