Besides liver cancer, RFC4 has been reported to be associated with several types of cancer, including prostate cancer, colon cancer non-small cell lung cancer and leukemia (LaTulippe et al., 2002; Jung, Choi & Kim, 2009; Erdogan et al., 2009; Barfeld et al., 2014). Here, RFC4 is linked to malignant colon neoplasm.