The results of KEGG analysis demonstrated that the most significant signaling pathways of DEGs were cell cycle, pathways in cancer, ECM-receptor interaction, arrhythmogenic right ventricular cardiomyopathy (ARVC), melanoma, PI3K-Akt signaling pathway, focal adhesion, vascular smooth muscle contraction, DNA replication and oocyte meiosis (Table 3). Here, AKT1 is linked to melanoma.