Regarding dendritic cell (DC) populations, there were no significant differences in numbers for the CD1c+ DCs, which is the most frequent blood DC population, or for the CD141+ DCs that are specialized in cross-presenting antigens to CD8+ T cells.16 However, DCs from uveal melanoma patients expressed reduced levels of the antigen-presentation molecule HLA-DR and the costimulatory molecule CD86 (Figure 1b,e). This evidence concerns the gene THBD and uveal melanoma.