Six years later, Buckley et al. [2] described two boys with severe dermatitis, a characteristic face, frequent infections, extremely high levels of serum IgE and eosinophilia, and termed the disease “Buckley's syndrome.” In 1974, Hill et al. [3, 4] found that patients with similar diseases had high levels of serum IgE and defects in the chemotactic function of granulocytes. Here, IGHE is linked to skin disorder.