CREB3L4 and cocaine dependence: However, gene expression in the cocaine addiction-related pathway (i.e., expression of CREB3L4, DLG4, GNAI2, GPSM1, GRIN2C, GRM2, NFKB1, and PPP1R1B in mmu05030, pathway identifier used in KEGG) was downregulated in CUMS mice treated with DBS (Supplementary Figure S6).