PRKCE and neuropathic pain: In addition, quercetin further modulates the activity of a variety of pathways, including Toll-like receptor, mTOR, protein kinase Cε (PKCε)-TRPV1, p70 ribosomal S6 kinase (p70S6K), and P2X4 receptor signalings, as well as oxidative stress- and inflammation-associated mediators to exert its analgesic effects against diverse types of neuropathic pain [214, 335–347].