METTL3 promotes development, progression and metastasis of PRAD through regulating MYC methylation, hedgehog pathway, and Wnt pathway (Cai et al., 2019; Ma et al., 2020; Yuan et al., 2020) and enhances bone metastasis through m6A-HuR-dependent mechanism (Li et al., 2020). This evidence concerns the gene METTL3 and prostate adenocarcinoma.