In PC, literatures link pathogenesis and progression of the tumor with m6A regulators that include METTL3 (Cai et al., 2019; Li et al., 2020; Ma et al., 2020; Yuan et al., 2020), VIRMA (Barros-Silva et al., 2020), YTHDF2, YTHDF3 (Li et al., 2018), and FTO (Melnik, 2015). This evidence concerns the gene YTHDF2 and pachyonychia congenita.