HNRNPA2B1 took part in many biological processes, such as cell survival regulation, cell cycle alteration, telomere maintenance, metastasis regulation, and cellular energetics regulation, and acted as a prognostic biomarker in multiple cancers including lung cancer, pancreas cancer, and hepatocellular cancer (Chen et al., 2017; Dai et al., 2017; Roy et al., 2017; Yu et al., 2018). This evidence concerns the gene HNRNPA2B1 and hepatocellular carcinoma.