The enhancer of PVR identified in this study was situated approximately 40 kb upstream of the promoter, and the correlation between the enhancer activity and gene expression was 0.78; PVR is actively transcribed in many cancers (Figure 6B), and the putative enhancer of PVR was found to be positively correlated with PVR gene expression across all examined cancer types (Supplementary Figure 14). Here, PVR is linked to cancer.