Importantly, 25.8% (=197/763) CAD-associated genes (e.g., ACER2, ACSS2, ARHGEF19, and BBS10) and 60.7% (=503/827) CKD-associated genes (e.g., BAG6, BAK1, BTNL2, and C4BPB) are likely novel genes because those genes are not nearby (within 1 Mb upstream and downstream) any previous GWAS index SNPs or associated genes in terms of the GWAS catalog (McMahon et al., 2019). This evidence concerns the gene ARHGEF19 and coronary artery disorder.