Specifically, prior studies showed that ARHGEF19 (Klarin et al., 2018) and LRP10 (Sugiyama et al., 2000) were associated with total cholesterol and low-density lipoprotein (LDL) cholesterol, which were in turn related to CAD (Nissen et al., 2005) and CKD (Baigent et al., 2011). The gene discussed is ARHGEF19; the disease is coronary artery disorder.