Guix and colleagues (Guix et al., 2017) reported that TSPAN6 was increased in Alzheimer’s disease brains and promoted Aβ-peptide accumulation by affecting the autophagosome–lysosomal pathway and slowing down the degradation of Amyloid precursor protein (APP)–C-terminal fragments. This evidence concerns the gene APP and early-onset autosomal dominant Alzheimer disease.