Our results strongly suggest an inverse relationship between the SETDB1 levels and EMT in lung tumors, which is in disagreement with the notion that overexpressed SETDB1 promotes metastasis, as reported in liver (Fei et al., 2015; Wong et al., 2016) and breast cancers (Weigelt et al., 2010; Ryu et al., 2019); this probably indicates that SETDB1 behaves differently in different cancers. The gene discussed is SETDB1; the disease is cancer.