SETDB1 gene copy number amplification (CNA) has been frequently observed in various cancers, including melanoma (Ceol et al., 2011), lung SCLC, and NSCLC (Rodriguez-Paredes et al., 2014), hepatocellular carcinoma (Wong et al., 2016), and breast cancer (Regina et al., 2016); a strong correlation between SETDB1 overexpression and cancer development has been detected in various cancers (Kang, 2018). Here, SETDB1 is linked to hepatocellular carcinoma.