AKT1 and breast carcinoma: Furthermore, we showed that miR-1291 is associated with negative regulation of various RTKs pathways, such as the PI3K/AKT, IGFR1, and FGFR3 signaling pathways that have a pivotal role in the regulation of cancer proliferation, angiogenesis, and metastasis in breast cancer (Butti et al., 2018).